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Does low-dose naltrexone change appetite

Does low-dose naltrexone change appetite

To get a deeper understanding of this, we would have to dig in. But yes! LDN can assist in modulating and reducing your appetite.

Before finding out how this might be beneficial let’s first acknowledge some basics regarding weight gain and weight loss:

  • Chronic calorie restriction doesn’t work for 99% of the time in order to sustain weight loss
  • Chronic calorie restriction increases the leptin levels and reduces the levels of free T3 and different hormone changes which result in weight gain with time
  • Chronic calorie restriction begins a compensatory metabolic transformation which causes damage in metabolism that might affect a person for years
  • Usually, prescription weight loss medicines affect either metabolism or appetite, and though they don’t accomplish results that well on a long term basis
  • Reducing appetite can result in long term metabolic damage, as it is observed in chronic phentermine use, once patients discontinue the medicine they get their weight back


Some of these modifications might appear scary but several ways exist to use specific medicines to avoid these consequences or to promote hormone alterations that can result in long-term weight loss. The way low-dose naltrexone controls appetite is quite similar.

Under the common physiologic circumstances, your body attempts to match the quantity of food you consume with your relaxed state energy expenditure, which is your metabolism. Your body does this to try to balance the caloric burn with food consumption. But this happens under normal conditions, what springs up in patients who experience hormone imbalances or those who are overweight?

In case you have a history of any dieting plan or chronic calorie restriction then the circumstances mentioned above do not apply to you. Chronic calorie restriction results in metabolic damage and that can lower your metabolic rate. Weight gain results in hormonal fluctuations especially raised leptin levels which modify your subjective sensation of hunger. This mismatch is produced by compensatory hormonal modifications, and these modifications are very strong.

So where can LDN fit in?

Low-dose naltrexone might help to “nullify” this mismatch that occurs between calories burned and hunger.

By balancing the 1,200 calories you burned to the 1,200 calories you took, you experience a decrease in appetite overall, but not in the “classical” sense.

As to keep in the notice, LDN won’t certainly improve your metabolism (because it takes a very long time depending on the amount of damage your body has gone through) but it’s a move in the accurate direction. Low-dose naltrexone might help to normalize hunger in people with damaged metabolism and that helps in balancing appetite with resting energy expenditure.

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